小鼠急性损伤模型，比较常见的是LPS诱导的急性腹膜炎小鼠模型；ConA 诱导的肝炎模型和盲肠结扎穿刺（CLP）诱导的败血症小鼠模型。如何在急性模型中清除巨噬细胞，可以参考如下这篇文献。

论文信息：

论文题目：Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

期刊名称：Nature Communications

时间期卷：11, Article number: 1769(2020)

在线时间：2020年4月14日

DOI： doi.org/10.1038/s41467-020-15636-8

产品信息：

货号：C-005

规格：5ml

品牌：Liposoma

产地：荷兰

名称：Clodronate Liposomes

办事处：Target Technology(靶点科技)

Clodronate Liposomes氯膦酸盐脂质体清除巨噬细胞介导的急性炎症模型 ，荷兰Liposoma巨噬细胞清除剂ClodronateLiposomes见刊于Nature Communications：糖原代谢调节巨噬细胞介导的急性炎症反应。

氯膦酸二钠脂质体ClodronateLiposomes清除三种急性损伤模型巨噬细胞解决方案：

Animal studies

In the LPS-induced acute peritonitis mouse model, C57BL/6J mice were treated with GPI (10?μg?g?1, i.p., 12 and 4?h before LPS injection), 6AN (15?μg?g?1, i.p., 12 and 4?h before LPS injection) or clodronate liposomes (Clod, 10?μL?g?1, i.p., 36 and 4?h before- and 36?h after- LPS injection), followed by i.p. injection of 20?μg?g?1 body weight LPS. In the ConA-induced hepatitis model, C57BL/6J mice were treated with GPI (10?μg?g?1, i.v., 12 and 4?h before ConA injection), 6AN (15?μg?g?1, i.v., 12 and 4?h before ConA injection) or clodronate liposomes (Clod, 10?μL?g?1, i.p., 36 and 4?h before- and 36?h after- ConA injection), followed by i.v. injection of 15?μg?g?1 body weight ConA. In the cecal ligation and puncture (CLP)-induced sepsis mouse model, C57BL/6J mice were treated with GPI (10?μg?g?1, i.p., 12 and 4?h before CLP procedure), 6AN (15?μg?g?1, i.p., 12 and 4?h before CLP procedure) or clodronate liposomes (10?μL?g?1, i.p., 36 and 4?h before- and 36?h after- CLP procedure), followed by CLP procedure.